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Product Certifications and Compliance

US Patent Protection

Patent protection is crucial to facilitate enhanced market exclusivity and prevent market entry of low cost substitutes. There are currently four approved US patents for HIDROX® and numerous patents pending approvals.

Approved Patents

  1. United States Patent Number 6,165,475, December 26, 2000. Water-soluble Extract From Olives.
  2. United States Patent Number 6,197,308, March 6 2001. Water-soluble Extract From Olives.
  3. United States Patent Number 6,416,808, July 9, 2002. Method of Obtaining A Hydroxytyrosol-Rich Composition From Vegetation Water.
  4. United States Patent Number 6,936,287, August 30, 2005. Water-soluble Extract From Olives.
  5. United States Patent Number 7,713,569, May 11, 2010. Hydroxytyrosol-Rich Composition From Olive Vegetarian Water And Method of Use Thereof

Certifications » Go to Top

Kosher Certification

IFANCA HALAL Product Certification

GRAS Status

HIDROX® has been granted GRAS status and during this determination the scientific evidence verifies the potency of our patented Olea europaea extract to be one of the most potent sources of antioxidant polyphenols with anti-inflammatory and anti-microbial properties ever prescribed in the botanical world.

"GRAS" is an acronym for the phrase "Generally Recognized As Safe". Under sections 201(s) and 409 of the Federal Food, Drug, and Cosmetic Act (the Act), any substance that is intentionally added to food is a food additive, that is subject to pre market review and approval by FDA, unless the substance is generally recognized, among qualified experts, as having been adequately shown to be safe under the conditions of its intended use, or unless the use of the substance is otherwise excluded from the definition of a food additive. For example, substances whose use meets the definition of a pesticide, a dietary ingredient of a dietary supplement, a colour additive, a new animal drug, or a substance approved for such use prior to September 6, 1958, are excluded from the definition of food additive. Sections 201(s) and 409 were enacted in 1958 as part of the Food Additives Amendment to the Act. While it is impracticable to list all ingredients whose use is generally recognized as safe, FDA published a partial list of food ingredients whose use is generally recognized as safe to aid the industry's understanding of what did not require approval.


Safety and Toxicity Studies with HIDROX® 6% for GRAS » Go to Top


  • (2001a) Acute dermal toxicity study of OLIVENOL™ administered to CD-1 mice. Primedica, Redfield, AR. Report Number: 150-001.
  • (2001b) Acute oral toxicity study of OLIVENOL™ administered to CD-1 mice. Primedica, Redfield, AR. Report Number: 150-004.
  • (2004a) In vitro chromosome aberration in Chinese hamster ovary cells for solid olive pulp extract (HIDROX®). Next Century Incorporated, Newark, DE. Report Number: 2016.
  • (2004b) Oral (gavage) developmental toxicity study of HIDROX® (solide olive pulp extract) in rats. Argus Incorporated, Horsham, PA.. Report Number: 3403-004.
  • (2004c) Oral (gavage) dosage-range reproductive study of solid olive pulp extract (HIDROX®) in rats. Argus Incorporated, Horsham, PA. Report Number: 3403-003P.
  • (2004d) Range finding study of solid olive pulp extract (HIDROX®) in rats. Argus Incorporated, Horsham, PA. Report Number: 3403-006.
  • (2004e) Repeated dose 90-day toxicity study of HIDROX® (solid olive pulp extract) in rats. Charles River Laboratories, Horsham, PA. Report Number: 3403-005.
  • (2004f) Solid olive pulp extract (HIDROX®): Bacterial reverse mutation test: Plate incorporation and preincubation methods for solids. Next Century Incorporated, Newark, DE.. Report Number: 2016.





Clinically Proven Benefits of HIDROX® » Go to Top




  • CREAGRI® & Arizona State University trial in arthritis:
  • Double blind, randomized, placebo-controlled study
  • 105 osteoarthritis/rheumatoid arthritis patients enrolled, 90 completed
  • Two capsules of HIDROX® 2% /day for eight weeks
  • HAQ improvement in OA patients at 8 weeks, plasma homocysteine decreased in RA patients

  • CREAGRI® & Tokyo Vascular Disease Institute trial in hyperlipidemia
  • Open label trial
  • 38 patients with hyperlipidemia or Takahashi’s Syndrome enrolled, 35 completed
  • Two capsules of HIDROX® 2% twice a day for six months
  • Serum V-LDL levels decreased in all patients, serum antioxidant activity increased in male patients

  • CREAGRI® & Tokyo Vascular Disease Institute trial in skin disorders
  • 10 patients with skin disorders including psoriasis purulenta, psoriasis erythematosus, seborrhea dermatitis and allergic dermatitis
  • Two capsules of HIDROX® 2% per day
  • Skin condition evaluated before and after treatment
  • Significant improvement seen after 60 days.


Request for Research Studies » Go to Top


At CREAGRI®, we are diligent in searching for information and topics related to our products. In the course of our reading expedition, we have come across many interesting articles ranging from olive related information, ingredient functions, supplement reviews right up to health and beauty tips, which we feel are beneficial to you. We have also accumulated an extensive list of journals, reports and fact sheets during our research and development of HIDROX®, and would like to share a few with you, hoping to aid you on your decision making in selecting supplements which are best suited to your needs.


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Select from this list of reference studies:
(Click on any of the reference titles for more details)
Neuroprotection
Human Antioxidant Potential
Mitochondrial Health and Aging
Anti-Viral and Anti-Microbial Activity
Food Protection
Skin Health
Cardiovsacular Health
Bone, Joint and Muscle Support






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